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Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells. Icariin was isolated from Treatment for Erection Problem herba. Cavernous smooth Sildenafil 100mg cells were isolated from 3-month-old rats, treated with icariin and microM or zaprinast microM for 15 minutes, and then with 10 microM SNP for 30, 60, and minutes.

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The addition of 10 microM icariin caused four times more mineralized bone nodules to be formed by rMSCs than in emotional health issues control. The results demonstrated that icariin should be an effective component for bone-strengthening activity, and one of the mechanisms is to stimulate the proliferation and enhance the osteogenic differentiation of MSCs.

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